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Product Name Anti-GPCR GPR6/AF350 Chinese Name AF350标记的G protein-coupled receptor6抗体 Alias G protein coupled receptor 6; GPR 6; GPR6; GPR6_HUMAN; Sphingosine 1 phosphate receptor GPR 6; Sphingosine 1 phosphate receptor GPR6. Research Area Cell biology Neurobiology Signal transduction G protein-coupled receptor G protein signal Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, ) Applications ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Molecular weight 38kDa Form Lyophilized or Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human GPCR GPR6 Lsotype IgG Purification affinity purified by Protein A Storage Buffer 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol Storage Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. Product Detail background:
G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. GPCR GPR6 is a member of this family (subfamily lysophospholipid/lysosphingolipid). GPR6 has been reported to be expressed in brain, particularly in the putamen, and to a lesser extent, in the frontal cortex, hippocampus, and hypothalamus. An EST has been isolated from a human brain (hypothalamus) library. GPCR GPR6 belongs to the G-protein coupled receptor 1 family. It is a receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular Location:
Cell membrane; Multi-pass membrane protein.
Similarity:
Belongs to the G-protein coupled receptor 1 family.
Database links:Entrez Gene: 2830 Human
Entrez Gene: 140741 Mouse
Omim: 600553 Human
SwissProt: P46095 Human
SwissProt: Q6YNI2 Mouse
Unigene: 46332 Human
Unigene: 32092 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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