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Product Name alpha 2 Macroglobulin Chinese Name α2巨球蛋白(α-2M)抗体 Alias A2M; α-2M; A2MG_HUMAN; Alpha 2 M; Alpha 2M; Alpha-2-M; Alpha-2-macroglobulin; Alpha-2 Macroglobulin; Alpha 2-Macroglobulin; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; CPAMD5; DKFZp779B086; FWP007; S863 7. literatures Specific References (3) | SL9505R has been referenced in 3 publications.[IF=3.7] Liu, Ranran, et al. "Uncovering the embryonic development-related proteome and metabolome signatures in breast muscle and intramuscular fat of fast-and slow-growing chickens." BMC Genomics 18.1 (2017): 816. WB ; Chicken.[IF=1.56] Hu, Hai Xia, et al. "Anti-inflammatory effects of Gualou Guizhi decoction in transient focal cerebral ischemic brains. Corrigendum in/mmr/12/3/3998." Molecular medicine reports 12.1 (2015): 1321-1327. IHC-P ; Rat.[IF=1.243] Shu et al. Differentially expressed serum proteins associated with calcium regulation and hypocalcemia in dairy cows. (2017) Asian-Australas.J.Anim.Sc. 30:893-901 WB ; Bovine.Research Area Cell biology immunology Neurobiology Immunogen Species Rabbit Clonality Polyclonal React Species Human, Chicken, (predicted: Mouse, Rat, Pig, Cow, Horse, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 160kDa Cellular localization Secretory protein Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human alpha 2 Macroglobulin: 751-850/1474 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008].
Function:
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.
Subunit:
Homotetramer; disulfide-linked.
Subcellular Location:
Secreted
Tissue Specificity:
Secreted in plasma
Similarity:
Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.
SWISS:
P01023
Gene ID:
2
Database links:Entrez Gene: 2 Human
Entrez Gene: 232345 Mouse
Omim: 103950 Human
SwissProt: P01023 Human
SwissProt: Q61838 Mouse
Unigene: 212838 Human
Unigene: 30151 Mouse
Unigene: 225884 Rat
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