Product Name	PDE3B
Chinese Name	环核苷酸磷酸二酯酶PDE3B抗体
Alias	5''-cyclic phosphodiesterase B; Adipocyte cAMP phosphodiesterase cGMP inhibited; AI847709; cAMP Phosphodiesterase, adipocyte, cGMP-inhibited; CGI-PDE B; CGIP1; CGIPDE B; CGIPDE1; cGMP inhibited 3 5 cyclic phosphodiesterase B; CGMP inhibited cAMP phophodiesterase; cGMP-inhibited 3''; Cyclic GMP inhibited phosphodiesterase B; Cyclic GMP-inhibited phosphodiesterase B; Cyclic nucleotide phosphodiesterase; HcGIP1; HcGIP1, rat, homolog of; Pde3b; PDE3B_HUMAN; Phosphodiesterase 3B cGMP inhibited.
literatures	Specific References  (1)     |     SL8621R has been referenced in 1 publications. [IF=7.419] Mingyan Shao. et al. Ginsenoside Rb3 upregulates sarcoplasmic reticulum Ca2+-ATPase expression and improves the contractility of cardiomyocytes by inhibiting the NF-κB pathway. BIOMED PHARMACOTHER. 2022 Oct;154:113661  WB ;  Mouse, Rat.   PubMed:10.1016/j.biopha.2022.113661
Research Area	Cell biology  Chromatin and nuclear signals  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human,  (predicted: Mouse, Rat, Dog, Pig, Horse, Rabbit, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	124kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PDE3B: 451-550/1112
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	PDE3B is found in lymphocytes. The PDE7A1 (HCP1) isozyme and the PDE7A2 proteins, alternate splice products of PDE7A, are highly expressed in skeletal muscle. PDE7B is most highly expressed in pancreas. The PDE family contains proteins that serve tissue-specific roles in regulation of lipolysis, glycogenolysis, myocardial contractility, and smooth muscle relaxation. Function: Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism. Subcellular Location: Membrane. Tissue Specificity: Abundant in adipose tissues. Similarity: Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily. SWISS: Q13370 Gene ID: 5140 Database links: Entrez Gene: 5140 Human Entrez Gene: 18576 Mouse Entrez Gene: 29516 Rat Omim: 602047 Human SwissProt: Q13370 Human SwissProt: Q61409 Mouse SwissProt: Q8CIX5 Mouse SwissProt: Q63085 Rat Unigene: 445711 Human Unigene: 430730 Mouse Unigene: 10322 Rat
Product Picture	Sample: K562(Human) Cell Lysate at 30 ug Primary: Anti- PDE3B (SL8621R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 124 kD Observed band size: 124 kD Sample: Hela(Human) Cell Lysate at 30 ug Primary: Anti- PDE3B (SL8621R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 124 kD Observed band size: 124 kD

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