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Product Name Etv5 Chinese Name 转录因子Ets差异基因5抗体 Alias ERM; Ets related protein ERM; ETS translocation variant 5; Ets variant gene 5; Ets-related protein ERM; Etv5; ETV5_HUMAN. literatures Specific References (3) | SL8592R has been referenced in 3 publications.[IF=3.26] Mu, Hailong, et al. "PLZF‐Induced Upregulation of CXCR4 Promotes Dairy Goat Male Germline Stem Cell Proliferation by Targeting Mir146a." Journal of Cellular Biochemistry (2015). Goat.[IF=3.12] Zheng, Liming, et al. "CD49f promotes proliferation of male dairy goat germline stem cells." Cell Proliferation (2016). Goat.[IF=1.06] Yuan, Quan, et al. "Human microvascular endothelial cell promotes the development of dorsal root ganglion neurons via BDNF pathway in a co-culture system." Bioscience, Biotechnology, and Biochemistry (2017): 1-8. WB ; Human.Research Area Tumour Stem cells transcriptional regulatory factor Epigenetics Immunogen Species Rabbit Clonality Polyclonal React Species Mouse, (predicted: Human, Rat, Dog, Pig, Cow, Horse, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 58kDa Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human ERM/Etv5: 301-385/510 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Rad and Gem related GTP binding protein (REM) is a member of the RGK subfamily of Ras-like GTPases that also includes Rad, REM2 and Gem/Kir. REM is a phosphorylated protein that is highly expressed in cardiac muscle and moderately expressed in lung, kidney and skeletal muscle. REM associates with several 14-3-3 isoforms as well as with calmodulin in a calcium-dependent manner. REM mediates two distinct signal transduction pathways that regulate both cytoskeletal reorganization and voltage-gated calcium channel activity. REM decreases the current that passes through cardiac voltage-gated L-type Ca channels (Ca(V)). Overexpression of REM may result in the development of cytoplasmic processes, reorganization of the Actin cytoskeleton, reduction in focal adhesion size and an elongated or dendritic-like cell morphology.
Function:
Binds to DNA sequences containing the consensus nucleotide core sequence GGAA.
Subcellular Location:
Ubiquitous.
Tissue Specificity:
Nucleus.
Similarity:
Belongs to the ETS family.
Contains 1 ETS DNA-binding domain.
SWISS:
P41161
Gene ID:
2119
Database links:Entrez Gene: 2119 Human
Entrez Gene: 104156 Mouse
Omim: 601600 Human
SwissProt: P41161 Human
SwissProt: Q9CXC9 Mouse
Unigene: 43697 Human
Unigene: 155708 Mouse
Unigene: 18397 Rat
Product Picture Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Etv5) Polyclonal Antibody, Unconjugated (SL8592R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining.
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