Product Name	GPX4
Chinese Name	谷胱甘肽过氧化酶4抗体
Alias	Glutathione peroxidase 4; GPX 4; GPX-4; GPX4; GPX4_HUMAN; GSHPx-4; MCSP; mitochondrial; PHGPx; Phospholipid hydroperoxidase; Phospholipid hydroperoxide glutathione peroxidase; Phospholipid hydroperoxide glutathione peroxidase; Phospholipid hydroperoxide glutathione peroxidase mitochondrial; snGPx; snPHGPx; Sperm nucleus glutathione peroxidase.
literatures	Specific References  (18)     |     SL3884R has been referenced in 18 publications. [IF=18.027] Ke Li. et al. Oxygen Self-Generating Nanoreactor Mediated Ferroptosis Activation and Immunotherapy in Triple-Negative Breast Cancer. ACS NANO. 2023;17(5):4667–4687  WB ;  Mouse.   PubMed:36861638 [IF=15.153] Xu Chen. et al. Chiral Ruthenium Nanozymes with Self-Cascade Reaction Driven the NO Generation Induced Macrophage M1 Polarization Realizing the Lung Cancer “Cocktail Therapy”. SMALL. 2023 Apr;:2207823  WB ;  Mouse.   PubMed:37029560 [IF=12.479] Tao Liu. et al. Multifaceted roles of a bioengineered nanoreactor in repressing radiation-induced lung injury. Biomaterials. 2021 Oct;277:121103  WB,IF ;  Mouse.   PubMed:34478930 [IF=10.753] Lu Yu. et al. Chronic arsenic exposure induces ferroptosis via enhancing ferritinophagy in chicken livers. SCI TOTAL ENVIRON. 2023 May;:164172  WB ;  Chicken.   PubMed:37201840 [IF=9.685] Hu, Xiaomeng. et al. PNO1 inhibits autophagy-mediated ferroptosis by GSH metabolic reprogramming in hepatocellular carcinoma. CELL DEATH DIS. 2022 Nov;13(11):1-12  WB ;  Human.   PubMed:36446769 [IF=7.675] Shuang Wang. et al. Dioscin Protects against Cisplatin-Induced Acute Kidney Injury by Reducing Ferroptosis and Apoptosis through Activating Nrf2/HO-1 Signaling. ANTIOXIDANTS-BASEL. 2022 Dec;11(12):2443  IF ;  Rat.   PubMed:36552651 [IF=7.31] Huang Bin. et al. Dapagliflozin Ameliorates Renal Tubular Ferroptosis in Diabetes via SLC40A1 Stabilization. OXID MED CELL LONGEV. 2022;2022:9735555  WB, IP ;  Mouse, Human.   PubMed:35993021 [IF=7.129] Zhaoqi He. et al. Cadmium induces liver dysfunction and ferroptosis through the endoplasmic stress-ferritinophagy axis. ECOTOX ENVIRON SAFE. 2022 Oct;245:114123  WB ;  Mouse.   PubMed:36183427 [IF=6.023] Lijuan Bao. et al. Ferritinophagy is involved in Bisphenol A-induced ferroptosis of renal tubular epithelial cells through the activation of the AMPK-mTOR-ULK1 pathway. Food Chem Toxicol. 2022 May;163:112909  WB ;  Mouse.   PubMed:35292335 [IF=4.872] Jing Ge. et al. Comparative study on protective effect of different selenium sources against cadmium-induced nephrotoxicity via regulating the transcriptions of selenoproteome. Ecotox Environ Safe. 2021 Jun;215:112135  WB ;   PubMed:33780782 [IF=4.872] Xiao Han. et al. ZEB1 directly inhibits GPX4 transcription contributing to ROS accumulation in breast cancer cells. Breast Cancer Res Tr. 2021 Jul;188(2):329-342  WB ;  Human.   PubMed:34169392 [IF=4.556] Andrea Kreheľová. et al. Characterization of Glutathione Peroxidase 4 in Rat Oocytes, Preimplantation Embryos, and Selected Maternal Tissues during Early Development and Implantation. Int J Mol Sci. 2021 Jan;22(10):5174  WB,IHC ;  Rat.   PubMed:34068371 [IF=4.014] Zhang Kaixin. et al. MiR-129-3p regulates ferroptosis in the liver of Selenium-deficient broilers by targeting SLC7A11. POULTRY SCIENCE. 2022 Oct;:102271  WB ;  Chicken.   PubMed:10.1016/j.psj.2022.102271 [IF=3.69] Sukfan P. Kwong. et al. PORIMIN: The key to (+)-Usnic acid-induced liver toxicity and oncotic cell death in normal human L02 liver cells. J Ethnopharmacol. 2021 Apr;270:113873  WB ;  Human.   PubMed:33485970 [IF=3.405] Jianwei Lei. et al. The protective mechanism of protein kinase R to inhibit neuronal ferroptosis in cerebral injury from subarachnoid hemorrhage. BRAIN BEHAV. 2022 Jul;:e2722  WB ;  Rat.   PubMed:35894766 [IF=3.231] Yajing Li. et al. Effect of Zearalenone-Induced Ferroptosis on Mice Spermatogenesis. ANIMALS. 2022 Jan;12(21):3026  WB ;  Mouse.   PubMed:36359150 [IF=3.076] Tang Q et al. Ferroptosis is newly characterized form of neuronal cell death in response to arsenite exposure.Neurotoxicology. 2018 Jul;67:27-36.  WB ;  Mouse.   PubMed:29678591 [IF=0] Lan B et al. Extract of Naotaifang, a compound Chinese herbal medicine, protects neuron ferroptosis induced by acute cerebral ischemia in rats. Journal of Integrative Medicine. 2020.  IHC-P ;  Rat.   PubMed:doi:10.1016/j.joim.2020.01.008
Research Area	Tumour  Cell biology  immunology  Signal transduction  The new supersedes the old  Mitochondrion
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Pig, Cow, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	22kDa
Cellular localization	cytoplasmic Mitochondrion
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Glutathione Peroxidase 4: 101-197/197
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Glutathione peroxidases (Gpxs) are ubiquitously expressed proteins which catalyze the reduction of hydrogen peroxides and organic hydroperoxides by glutathione. There are several isoforms which differ in their primary structure and localization. The classical cytosolic/mitochondrial GPx1 (cGPx) is a selenium-dependent enzyme, first of the GPx family to be discovered. GPx2, also known as gastrointestinal GPx (GI-GPx), is an intracellular enzyme expressed only at the epithelium of the gastrointestinal tract. Extracellular plasma GPx (pGPx or GPx3) is mainly expressed by the kidney from where it is released into the blood circulation. Phospholipid hydroperoxide GPx4 (PH-GPx) expressed in most tissues, can reduce many hydroperoxides including hydroperoxides integrated in membranes, hydroperoxy lipids in low density lipoprotein or thymine. All mammalian GPx family members, except for the recently described Cys containing GPx3 and epididymis-specific secretory GPx (eGPx or GPx5) isoforms, possess selenocysteine at the active site. Function: Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage. Subunit: Monomer. Has a tendency to form higher mass oligomers. Subcellular Location: Isoform Mitochondrial: Mitochondrion. Isoform Cytoplasmic: Cytoplasm. Tissue Specificity: Present primarily in testis. Similarity: Belongs to the glutathione peroxidase family. SWISS: P36969 Gene ID: 2879 Database links: Entrez Gene: 2879 Human Entrez Gene: 625249 Mouse Entrez Gene: 29328 Rat Omim: 138322 Human SwissProt: P36969 Human SwissProt: O70325 Mouse SwissProt: P36970 Rat Unigene: 433951 Human Unigene: 359573 Mouse Unigene: 3647 Rat 谷胱甘肽过氧化物酶（GSH-Px）是机体内广泛存在的一种重要的过氧化物分解酶。硒是GSH-Px酶系的组成成分，它能催化GSH变为GSSG，使有毒的过氧化物还原成无毒的羟基化合物，同时促进H2O2的分解，从而保护The cell membrane的结构及功能不受过氧化物的干扰及损害。GSH-Px的活性中心是硒半胱氨酸，其活力大小可以反映机体硒水平。GSH-Px酶系主要包括4种不同的GSH-Px，分别为胞浆GSH-Px、血浆GSH-Px、磷脂氢过氧化物GSH-Px及胃肠道专属性GSH-Px。胞浆GSH-Px由4个相同的分子量大小为22kDa的亚基构成四聚体，每个亚基含有1个分子硒半胱氨酸，广泛存在于机体内各个组织，以肝脏红细胞为最多。它的生理功能主要是催化GSH参与过氧化反应，清除在细胞呼吸代谢过程中产生的过氧化物和羟自由基，从而减轻The cell membrane多不饱和脂肪酸的过氧化作用。
Product Picture	Sample: Kidney (mouse) Lysate at 40 ug Primary: Anti-GPX4 (SL3884R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 22kD Observed band size: 20 kD Sample: Testis (Mouse) Lysate at 40 ug Primary: Anti-GPX4 (SL3884R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 22 kD Observed band size: 19 kD Sample: Lane 1: Testis (Mouse) Tissue Lysate at 40 ug Lane 2: Liver (Mouse) Tissue Lysate at 40 ug Lane 3: Kidney (Mouse) Tissue Lysate at 40 ug Lane 4: Heart (Mouse) Tissue Lysate at 40 ug Lane 5: Testis (Rat) Tissue Lysate at 40 ug Lane 6: Liver (Rat) Tissue Lysate at 40 ug Lane 7: Kidney (Rat) Tissue Lysate at 40 ug Lane 8: Heart (Rat) Tissue Lysate at 40 ug Lane 9: U937 (Human) Cell Lysate at 30 ug Lane 10: HepG2 (Human) Cell Lysate at 30 ug Lane 11: MCF-7 (Human) Cell Lysate at 30 ug Lane 12: Huvec (Human) Cell Lysate at 30 ug Lane 13: 293T (Human) Cell Lysate at 30 ug Primary: Anti-GPX4 (SL3884R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 22 kD Observed band size: 20-22 kD

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