Product Name	GPX1
Chinese Name	谷胱甘肽过氧化酶1
Alias	Glutathione peroxidase 1; Cellular glutathione peroxidase; GPx 1; GPx-1; GPX1; GPX1_HUMAN; GSHPx-1; GSHPX1; MGC14399; MGC88245.
literatures	Specific References  (11)     |     SL3882R has been referenced in 11 publications. [IF=6.291] Changjiang Liu. et al. JNK and Jag1/Notch2 co-regulate CXCL16 to facilitate cypermethrin-induced kidney damage. ECOTOX ENVIRON SAFE. 2022 Jun;238:113582  WB ;  Rat.   PubMed:35512476 [IF=6.208] Yanan Hao. et al. Alginate Oligosaccharides Repair Liver Injury by Improving Anti-Inflammatory Capacity in a Busulfan-Induced Mouse Model. INT J MOL SCI. 2023 Jan;24(4):3097  WB ;  Mouse.   PubMed:36834506 [IF=6.1] Yun, Yang, et al. "Sulfate Aerosols Promote Lung Cancer Metastasis by Epigenetically Regulating the Epithelial-to-Mesenchymal Transition (EMT)." Environmental Science & Technology (2017).  WB ;  Human.   PubMed:28901751 [IF=5.23] Zhao, Yong, et al. "Hydrogen Sulfide and/or Ammonia Reduces Spermatozoa Motility through AMPK/AKT Related Pathways." Scientific Reports 6 (2016): 37884.  WB ;  Pig.   PubMed:27883089 [IF=5.195] Xinyu Wang. et al. Berberine modulates gut microbiota to attenuate cerebral ferroptosis induced by ischemia-reperfusion in mice. EUR J PHARMACOL. 2023 May;:175782  WB,IF ;  Mouse.   PubMed:37245860 [IF=4.546] Kuankuan Xiong. et al. Low-Concentration T-2 Toxin Attenuates Pseudorabies Virus Replication in Porcine Kidney 15 Cells. Toxins. 2022 Feb;14(2):121  WB ;  Pig.   PubMed:35202147 [IF=4.2] Zhang, Weidong, et al. "Decrease in male mouse fertility by hydrogen sulfide and/or ammonia can Be inheritable." Chemosphere (2017).  IHC-P ;  Mouse.   PubMed:29202267 [IF=3.85] Wang, Yandi, et al. "Regulation of steroid hormones and energy status with cysteamine and its effect on spermatogenesis." Toxicology and Applied Pharmacology (2016).  IHC-P ;  Sheep.   PubMed:27815134 [IF=2.89] Miyamoto, Kazuyuki, et al. "PACAP38 Suppresses Cortical Damage in Mice with Traumatic Brain Injury by Enhancing Antioxidant Activity." Journal of Molecular Neuroscience (2014): 1-10.  WB ;  Mouse.   PubMed:24907941 [IF=2.752] Shanshan Wang. et al. Effects of Coated Cysteamine on Oxidative Stress and Inflammation in Weaned Pigs. Animals-Basel. 2021 Aug;11(8):2217  WB ;  Pig.   PubMed:10.3390/ani11082217 [IF=2.323] Liu R et al. Effect of Dietary Methionine Deficiency Followed by a Re-Feeding Phase on the Hepatic Antioxidant Activities of LambsAnimals (Basel).2020 Dec 23;11(1):7.  WB ;  Lamb.   PubMed:33374518
Research Area	Tumour  Cardiovascular  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Sheep,  (predicted: Rat, Dog, Pig, Cow, Horse, Guinea Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=2ug/Test IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	22kDa
Cellular localization	cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from mouse Glutathione Peroxidase 1: 51-150/201
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene product belongs to the family of glutathione peroxidase, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq]. Subunit: Homotetramer. Interacts with MIEN1 (By similarity). Subcellular Location: Cytoplasm. Similarity: Belongs to the glutathione peroxidase family. SWISS: P11352 Gene ID: 2876 Database links: Entrez Gene: 461015 Chimpanzee Entrez Gene: 281209 Cow Entrez Gene: 2876 Human Entrez Gene: 706732 Macaque Monkey Entrez Gene: 14775 Mouse Entrez Gene: 100438450 Orangutan Entrez Gene: 397403 Pig Entrez Gene: 24404 Rat Omim: 138320 Human SwissProt: Q0EFA0 Chimpanzee SwissProt: P00435 Cow SwissProt: P07203 Human SwissProt: Q865R2 Macaque Monkey SwissProt: P11352 Mouse SwissProt: Q4AEI3 Orangutan SwissProt: Q8MJ14 Pig SwissProt: P04041 Rat Unigene: 76686 Human Unigene: 1090 Mouse Unigene: 11323 Rat 保护红细胞中血红蛋白的氧化分解.
Product Picture	Sample: Spleen (Mouse) Lysate at 40 ug Primary: Anti- GPX1 (SL3882R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 22 kD Observed band size: 22 kD Blank control:U937. Primary Antibody (green line): Rabbit Anti-GPX1 antibody (SL3882R) Dilution: 2μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody : Goat anti-rabbit IgG-PE Dilution: 1μg /test. Protocol The cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 0.1% PBST for 20 min at PBST. The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed.

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