Product Name	EPX
Chinese Name	嗜酸性粒细胞过氧化物酶抗体
Alias	Eosinophil peroxidase; Eosinophil peroxidase heavy chain; EPER; EPO; EPP; EPX PEN; PERE; PERE_HUMAN.
literatures	Specific References  (10)     |     SL3881R has been referenced in 10 publications. [IF=5.923] Geunyeong Kim. et al. Der f 38 Is a Novel TLR4-Binding Allergen Related to Allergy Pathogenesis from Dermatophagoides farinae. Int J Mol Sci. 2021 Jan;22(16):8440  IHC ;  Mouse.   PubMed:34445142 [IF=5.714] Jialiang Luo. et al. D-Mannose ameliorates DNCB-induced atopic dermatitis in mice and TNF-α-induced inflammation in human keratinocytes via mTOR/NF-κB pathway. INT IMMUNOPHARMACOL. 2022 Dec;113:109378  IHC ;  Mouse.   PubMed:36327873 [IF=4.741] Silva FMCE et al. High‐fat‐diet induced obesity worsens TH2 immune response and immunopathologic characteristics in murine model of Eosinophilic Esophagitis. Clin Exp Allergy. 2019 Dec 14.  IHF-P ;  Mouse.   PubMed:31837231 [IF=4.451] Xi Chen. et al. The protective effects of human milk components, 2′-fucosyllactose and osteopontin, against 2,4-dinitrochlorobenzene-induced atopic dermatitis in mice. J Funct Foods. 2021 Dec;87:104806  IHC ;  Mouse.   PubMed:10.1016/j.jff.2021.104806 [IF=3.754] Moreno-Villegas,et al.Activation of bombesin receptor Subtype-3 by [D-Tyr6,β-Ala11,Phe13,Nle14]bombesin6-14 increased glucose uptake and lipogenesis in human and rat adipocytes.(2018) Molecular and Cellular Endocrinology. :.  IF(ICC) ;  Rat.   PubMed:29402494 [IF=3.448] Sun X et al. Differential protein expression profiling by iTRAQ‐2D‐LC‐MS/MS of rats treated with oxaliplatin. J Cell Biochem. 2019 Jun 25.  IHC-P ;  Rat.   PubMed:31237037 [IF=2.629] Yu Wen-Yan. et al. Acupuncture Alleviates Menstrual Pain in Rat Model via Suppressing Eotaxin/CCR3 Axis to Weak EOS-MC Activation. Evid-Based Compl Alt. 2022;2022:4571981  IHC ;  Rat.   PubMed:35069759 [IF=2.608] Lin L et al. Toll-like receptor 4 attenuates a murine model of atopic dermatitis through inhibition of langerin-positive DCs migration.Experimental Dermatology, 2018 27(9), 1015–1022.  IHC-P ;  Mouse.   PubMed:10.1111/exd.13698 [IF=2.608] Lin L et al. Toll-like receptor 4 attenuates a murine model of atopic dermatitis through inhibition of langerin-positive DCs migration. Experimental Dermatology,2018 27(9), 1015–1022.  ELISA ;  Mouse.   PubMed:doi:10.1111/exd.13698 [IF=2.525] Thais Fantozzi,et al.Acute lung injury induced by intestinal ischemia and reperfusion is altered in obese female mice.(2018) Pulmonary Pharmacology & Therapeutics. 49:54-59.  IHC ;  Mouse.   PubMed:29337267
Research Area	Tumour  immunology
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	79kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human Eosinophil peroxidase heavy chain: 601-715/715
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	EPX, eosinophil peroxidase, is an antimycobacterial protein that localizes to cytoplasmic granules of eosinophils and recruits bromide to generate a halogenating oxidant. EPX dependent generation of hypobromous acid causes damage to tissue during inflammatory conditions that include asthma, allergies,cancer and parasitic/helminthic infections. EPX is a major enzyme present in eosinophils and upon degranulation, becomes released into the airways of asthmatics. As a result of its cationic nature and its ability to catalyze the formation of highly toxic oxidants, EPX can induce lung injury in a JNK dependent manner. Function: Mediates tyrosine nitration of secondary granule proteins in mature resting eosinophils. Shows significant inhibitory activity towards Mycobacterium tuberculosis H37Rv by inducing bacterial fragmentation and lysis. Subunit: Tetramer of two light chains and two heavy chains. Subcellular Location: Cytoplasmic granule. Note=Cytoplasmic granules of eosinophils. DISEASE: Defects in EPX are the cause of eosinophil peroxidase deficiency (EPD) [MIM:261500]. EPD is an autosomal recessive defect where anomalous eosinophils are characterized by nuclear hypersegmentation, hypogranulation, and negative peroxidase and phospholipid staining. Similarity: Belongs to the peroxidase family. XPO subfamily. SWISS: P11678 Gene ID: 8288 Database links: UniProtKB/Swiss-Prot: P11678.2
Product Picture	Tissue/cell: mouse stomach tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-EPX Polyclonal Antibody, Unconjugated(SL3881R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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