Product Name	ALOX12
Chinese Name	12脂氧合酶抗体
Alias	12 Lox; 12(S) lipoxygenase; 12S LOX; Alox 12; Alox12L; Alox15; Arachidonate 12 lipoxygenase 12S type; Arachidonate 12 lipoxygenase; Arachidonate 12 lipoxygenase leukocyte type; Arachidonate 12 lipoxygenase, 12S type; Arachidonate 12 lipoxygenase, leukocyte type; EC1.13.11.31; LOG 12; LOG12; Platelet type 12 lipoxygenase; Platelet type lipoxygenase 12; P-12-LOX; LOX12_HUMAN; 12 Lipoxygenase.
literatures	Specific References  (3)     |     SL3874R has been referenced in 3 publications. [IF=8.101] Jin Wang. et al. Irisin protects against sepsis-associated encephalopathy by suppressing ferroptosis via activation of the Nrf2/GPX4 signal axis. FREE RADICAL BIO MED. 2022 Jul;187:171  WB ;  Mouse.   PubMed:35660523 [IF=7.328] Dongdong Yao. et al. Matrix stiffness regulates bone repair by modulating 12-lipoxygenase-mediated early inflammation. Mat Sci Eng C-Mater. 2021 Sep;128:112359  WB ;  Rat.   PubMed:34474906 [IF=4.932] Zhikun Zhan. et al. Effect of oridonin on oxylipins in the livers of mice with acute liver injury induced by D-galactosamine and lipopolysaccharide. Int Immunopharmacol. 2021 Nov;:108387  WB ;  Mouse.   PubMed:34838489
Research Area	Tumour  Cardiovascular  immunology  transcriptional regulatory factor  Kinases and Phosphatases  Synthesis and Degradation
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse,  (predicted: Rat, Cow, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	76kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human 12 Lipoxygenase: 101-200/663
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a member of the lipoxygenase family of proteins. The encoded enzyme acts on different polyunsaturated fatty acid substrates to generate bioactive lipid mediators including eicosanoids and lipoxins. The encoded enzyme and its reaction products have been shown to regulate platelet function. Elevated expression of this gene has been observed in pancreatic islets derived from human diabetes patients. Allelic variants in this gene may be associated with susceptibility to toxoplasmosis. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017] Function: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation. {ECO:0000269|PubMed:16638750, Subcellular Location: Cytoplasm, cytosol. Membrane. Note=Membrane association is stimulated by EGF. Tissue Specificity: Expressed in vascular smooth muscle cells. DISEASE: Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. {ECO:0000269|PubMed:17460548}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry. Gln at position 261 may confer interindividual susceptibility to esophageal cancer (PubMed:17460548). {ECO:0000269|PubMed:17460548}. Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. {ECO:0000269|PubMed:17151091}. Note=Disease susceptibility may be associated with variations affecting the gene represented in this entry. Gln at position 261 may confer interindividual susceptibility to colorectal cancer (PubMed:17460548). {ECO:0000269|PubMed:17460548}. Similarity: Belongs to the lipoxygenase family. SWISS: P18054 Gene ID: 239 Database links: Entrez Gene: 239 Human Omim: 152391 Human SwissProt: P18054 Human Unigene: 654431 Human
Product Picture	Sample: Raw264.7 Cell Lysate at 40 ug A431 Cell Lysate at 40 ug Primary: Anti-ALOX12 (SL3874R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 73 kD Observed band size: 73 kD Sample: Lane 1: Esophagus (Mouse) Lysate at 40 ug Lane 2: A431 (Human) Cell Lysate at 30 ug Lane 3: Hela (Human) Cell Lysate at 30 ug Lane 4: A549 (Human) Cell Lysate at 30 ug Lane 5: 293T (Human) Cell Lysate at 30 ug Lane 6: U937 (Human) Cell Lysate at 30 ug Lane 7: K562 (Human) Cell Lysate at 30 ug Primary: Anti- ALOX12 (SL3874R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 76 kD Observed band size: 76 kD

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