Product Name	Anti-BEGAIN/APC
Chinese Name	APC标记的大脑富含鸟苷酸激酶相关蛋白抗体
Alias	BEGAIN; BEGIN; Brain enriched guanylate kinase associated protein; Brain-enriched guanylate kinase-associated homolog (rat); KIAA1446; SAP90/PSD95 Associated Proteins; SAPAP; BEGIN_HUMAN.
Research Area	Cell biology  Neurobiology  Cell type markers
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	(predicted: Human, Mouse, Rat, Dog, Cow, Horse, Sheep, )
Applications	ICC=1:50-200 IF=1:50-200  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Molecular weight	65kDa
Form	Lyophilized or Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human BEGAIN
Lsotype	IgG
Purification	affinity purified by Protein A
Storage Buffer	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Product Detail	background: BEGAIN is a 593 amino acid protein that localizes to cytoplasm and membrane. BEGAIN interacts with PSD-95 and SAPAP1 and forms a ternary complex and may sustain the structure of the postsynaptic density (PSD). BEGAIN is a novel PSD component associated with the core complex of PSD-95 and SAPAP. Because BEGAIN and SAPAP interact with the same region of PSD-95, BEGAIN and SAPAP may compete for the binding to PSD-95 and cannot interact with PSD-95 simultaneously. The C-terminal region of BEGAIN is involved in the interaction with PSD-95 whereas the N-terminal region has a coiled-coil structure that may interact with other molecules. BEGAIN is specifically expressed in brain and enriched in the PSD fraction. BEGAIN is also expressed in neurons and enriched at synaptic junctions, and is likely involved in the organization of synaptic junction components. Function: Brain-enriched guanylate kinase-associated protein (BEGAIN) interacts with postsynaptic density (PSD)-95/synapse-associated protein (SAP) 90. BEGAIN has been detected in nuclei and at synapses in neurons. Subunit: Interacts with DLG4 and DLGAP1 and forms a ternary complex (By similarity). Subcellular Location: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Database links: Entrez Gene: 57596 Human Entrez Gene: 380785 Mouse Entrez Gene: 79146 Rat Entrez Gene: 443287 Sheep SwissProt: Q9BUH8 Human SwissProt: Q68EF6 Mouse SwissProt: O88881 Rat SwissProt: Q6R6L0-4 Sheep Unigene: 211751 Human Unigene: 342085 Mouse Unigene: 30036 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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