Product Name	LGI3
Chinese Name	Lgi3蛋白抗体
Alias	Leucine rich repeat LGI family member 3; Leucine-rich glioma inactivated protein 3; Leucine-rich glioma-inactivated protein 3; Leucine-rich repeat LGI family member 3; LGI1 like protein 4; LGI1-like protein 4; LGI3; LGI3_HUMAN; LGIL4.
Research Area	Cell biology  Developmental biology  Neurobiology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,  (predicted: Human, Dog, Pig, Horse, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	59kDa
Cellular localization	cytoplasmic The cell membrane Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human LGI3: 101-220/548
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic å/∫ horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. Leucine-rich glioma-inactivated protein 3 (LGI3), also known as LGI1-like protein 4 (LGIL4) or leucine-rich repeat LGI family member 3, is a 548 amino acid secretory protein. LGI3 contains five LRR repeats and seven EAR repeats. Widely expressed, with highest levels in brain and lung, LGI3 has been shown to colocalize with endocytosis-associated proteins, lipid raft markers, and Syntaxin. The gene encoding LGI3 maps to chromosome 8p21.3. Function: May participate in the regulation of neuronal exocytosis. Subunit: Interacts with STX1A Subcellular Location: Secreted (Potential). Cytoplasmic vesicle, secretory vesicle, synaptic vesicle (By similarity). Cell junction, synapse, synaptosome (By similarity). Note=Found in the synaptosomal membrane fraction Tissue Specificity: Widely expressed, with highest levels in brain and lung. Similarity: Contains 7 EAR repeats. Contains 3 LRR (leucine-rich) repeats. Contains 1 LRRCT domain. Contains 1 LRRNT domain. SWISS: Q8N145 Gene ID: 203190 Database links: Entrez Gene: 203190 Human Entrez Gene: 213469 Mouse Entrez Gene: 306013 Rat Omim: 608302 Human SwissProt: Q8N145 Human SwissProt: Q8K406 Mouse
Product Picture	Sample: Cerebrum (Mouse) Lysate at 40 ug Cerebral cortex (Mouse) Lysate at 40 ug Lung (Mouse) Lysate at 40 ug Hippocampus (Mouse) Lysate at 40 ug Primary: Anti- LGI3 (SL11879R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 59 kD Observed band size: 59 kD Paraformaldehyde-fixed, paraffin embedded (rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (LGI3) Polyclonal Antibody, Unconjugated (SL11879R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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