Product Name	LZIC
Chinese Name	LZIC蛋白抗体
Alias	Leucine zipper and CTNNBIP1 domain containing protein; Leucine zipper and ICAT homologous domain containing protein; leucine zipper domain and ICAT homologous domain containing; LZIC antibodyprotein LZIC; LZIC_HUMAN.
Research Area	Tumour  Cell biology  Neurobiology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	21kDa
Cellular localization	The nucleus cytoplasmic
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human LZIC: 31-130/190
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	LZIC is a 190 amino acid protein that belongs to the CTNNBIP1 family. Ubiquitously expressed, LZIC is found at highest levels in kidney and is upregulated in a few gastric carcinomas. The gene encoding LZIC maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma. Function: LZIC belongs to the CTNNBIP1 family. It is ubiquitously expressed with highest levels in kidney. LZIC is up-regulated in several cases of gastric cancers. Subunit: Does not interact with CTNNB1 Tissue Specificity: Ubiquitously expressed, with highest levels in kidney. Up-regulated in several cases of gastric cancers. Similarity: Belongs to the CTNNBIP1 family. SWISS: Q8WZA0 Gene ID: 84328 Database links: Entrez Gene: 419445 Chicken Entrez Gene: 84328 Human Entrez Gene: 69151 Mouse Entrez Gene: 366507 Rat Entrez Gene: 550045 Xenopus tropicalis Entrez Gene: 436871 Zebrafish Omim: 610458 Human SwissProt: Q5ZKW2 Chicken SwissProt: Q8WZA0 Human SwissProt: Q8K3C3 Mouse SwissProt: Q5PQN7 Rat SwissProt: Q28D79 Xenopus tropicalis
Product Picture	Paraformaldehyde-fixed, paraffin embedded (mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (LZIC) Polyclonal Antibody, Unconjugated (SL11638R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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