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Product Name Sec8 Chinese Name 胞吐分泌蛋白Sec8抗体 Alias dSec8; EXOC 4; Exoc4; EXOC4_HUMAN; Exocyst complex component 4; Exocyst complex component Sec8; KIAA1699; MGC27170; REC 8; REC8; rSec 8; Sec 8; Sec 8p; Sec8; SEC8 like 1; SEC8 protein; Sec8L1; Sec8p. Research Area Cell biology Neurobiology Immunogen Species Rabbit Clonality Polyclonal React Species Human, (predicted: Mouse, Rat, Cow, Horse, Rabbit, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 110kDa Cellular localization The nucleus cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human Sec8: 10-110/974 Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail The protein encoded by this gene is a component of the exocyst complex, a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast, the component proteins and functions of exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. The complex is also essential for the biogenesis of epithelial cell surface polarity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Function:
Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.
Subunit:
The exocyst complex is composed of EXOC1, EXOC2, EXOC3, EXOC4, EXOC5, EXOC6, EXOC7 and EXOC8. Interacts with BIRC6/bruce. Interacts with MYRIP.
Similarity:
Belongs to the SEC8 family.
SWISS:
Q96A65
Gene ID:
60412
Database links:Entrez Gene: 60412 Human
Entrez Gene: 20336 Mouse
Omim: 608185 Human
SwissProt: Q96A65 Human
SwissProt: O35382 Mouse
Unigene: 321273 Human
Unigene: 265512 Mouse
Unigene: 51841 Rat
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