Product Name	PLAGL1
Chinese Name	多型性腺瘤基因样蛋白1抗体
Alias	DKFZp781P1017; Lost on transformation 1; Lost on Transformation; LOT-1; LOT1; MGC126275; MGC126276; PLAG like 1; PLAGL1; PLAL1_HUMAN; Pleiomorphic adenoma gene like 1; Pleiomorphic adenoma gene like protein 1; Pleiomorphic adenoma-like protein 1; Tumor supressor ZAC; ZAC; ZAC tumor supressor; ZAC1; Zinc finger protein PLAGL1.
Research Area	Neurobiology  Stem cells  transcriptional regulatory factor  Epigenetics
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Dog, Pig, Zebrafish, )
Applications	ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	51kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PLAGL1: 1-100/463
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes a C2H2 zinc finger protein with transactivation and DNA-binding activities. It has been shown to have anti-proliferative properties, and thus thought to function as a tumor suppressor. In addition, overexpression of this gene during fetal development is believed to underlie the rare disorder, transient neonatal diabetes mellitus (TNDM). This gene is imprinted, with preferential expression of the paternal allele in many tissues, however, biallelic expression has been noted in peripheral blood leucocytes. A recent study reports that tissue-specific imprinting results from variable utilization of monoallelic and biallelic promoters. Many transcript variants differing in the 5' UTR and encoding two different isoforms, have been found for this gene. [provided by RefSeq, Oct 2010]. Function: Shows weak transcriptional activatory activity. Transcriptional regulator of the type 1 receptor for pituitary adenylate cyclase-activating polypeptide. Subunit: Interacts with THRSP. Subcellular Location: Nucleus. Similarity: Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 7 C2H2-type zinc fingers. SWISS: Q9UM63 Gene ID: 5325 Database links: Entrez Gene: 5325 Human Entrez Gene: 22634 Mouse Entrez Gene: 25157 Rat Entrez Gene: 421664 Chicken Omim: 603044 Human SwissProt: Q9UM63 Human Unigene: 725973 Human Unigene: 287857 Mouse Unigene: 6977 Rat
Product Picture	Paraformaldehyde-fixed, paraffin embedded (mouse colon); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PLAGL1) Polyclonal Antibody, Unconjugated (SL11206R) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.

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