Product Name	PCDHA11
Chinese Name	原钙粘蛋白11抗体
Alias	PCDHA 11; PCDHA-11; Protocadherin alpha-11; Protocadherin alpha 11; PCDAB_HUMAN.
Research Area	Neurobiology  Signal transduction  Cytoskeleton
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, Dog, Cow, Horse, Sheep, )
Applications	WB=1:500-2000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	100kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human PCDHA11: 351-450/949 <Extracellular>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Protocadherins are a large family of cadherin-like cell adhesion proteins that are involved in the establishment and maintenance of neuronal connections in the brain. There are three protocadherin (PCDH) gene clusters, designated alpha, beta and gamma, all of which contain multiple tandemly arranged genes. The protein products of PCDH-alpha genes interact with Integrin ∫1 to promote cell adhesion and form oligomers with PCDH-gamma proteins at specific membrane sites. PCDHA11 is a 949 amino acid single-pass transmembrane protein that contains six cadherin domains and functions as a potential calcium-dependent cell-adhesion protein, possibly playing a role in the creation and maintenance of neuronal connections. There are two isoforms of PCDHA11 that are produced as a result of alternative splicing events. Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. Subcellular Location: Cell membrane; Single-pass type I membrane protein (By similarity). Similarity: Contains 6 cadherin domains. SWISS: Q9Y5I1 Gene ID: 56138 Database links: Entrez Gene: 56138 Human SwissProt: Q9Y5I1 Human
Product Picture	Sample:Rsc96 Cell (Rat)Cell Lysate at 40 ug Primary: Anti-PCDHA11(SL11124R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-RabbitIgG at 1/20000 dilution Predicted band size: 100kD Observed band size: 110kD

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