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Product Name EVA1 Chinese Name 髓鞘蛋白P0样蛋白2抗体 Alias Epithelial V like antigen 1; epithelial V-like antigen; EVA; EVA1; MPZL2; MPZL2 myelin protein zero like 2; myelin protein zero-like 2; Myelin protein zero like protein 2; MPZL2_HUMAN. literatures Specific References (1) | SL11080R has been referenced in 1 publications.[IF=8.469] Wang, Xiaosong. et al. Serum-derived extracellular vesicles facilitate temozolomide resistance in glioblastoma through a HOTAIR-dependent mechanism. CELL DEATH DIS. 2022 Apr;13(4):1-11 WB ; Human.Research Area Neurobiology Cell adhesion molecule Cytoskeleton Extracellular matrix Transmembrane protein Immunogen Species Rabbit Clonality Polyclonal React Species (predicted: Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, ) Applications WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (Paraffin sections need antigen repair)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.Theoretical molecular weight 22kDa Cellular localization cytoplasmic The cell membrane Form Liquid Concentration 1mg/ml immunogen KLH conjugated synthetic peptide derived from human MPZL2/EVA1: 61-160/215 <Extracellular> Lsotype IgG Purification affinity purified by Protein A Buffer Solution 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. Storage Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. Attention This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. PubMed PubMed Product Detail Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for casein kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Function:
Mediates homophilic cell-cell adhesion.
Subcellular Location:
Cell Membrane; Single-pass type I membrane protein, cytoskeleton
Tissue Specificity:
Expressed in thymocytes and thymic stromal cells; expression elevated in some T-cell leukemias.
Similarity:
Belongs to the myelin P0 protein family.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
SWISS:
O60487
Gene ID:
10205
Database links:Entrez Gene: 10205 Human
Omim: 604873 Human
SwissProt: O60487 Human
Unigene: 116651 Human
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