Product Name	MCP1
Chinese Name	单核细胞趋化蛋白1抗体
Alias	MCP-1/CCL2; C-C motif chemokine 2; CCL 2; CCL2; CCL2_HUMAN; Chemokine (C C motif) ligand 2; Chemokine C C motif ligand 2; Chemokine CC Motif Ligand 2; GDCF 2; GDCF 2 HC11; GDCF-2; GDCF2; HC11; HSMCR30; HSMCR30; JE; MCAF; MCP 1; MCP-1; MGC9434; Monocyte chemoattractant protein 1; Monocyte chemotactic and activating factor; Monocyte chemotactic protein 1; Monocyte secretory protein JE; SCYA2; Small inducible cytokine A2 (monocyte chemotactic protein 1, homologous to mouse Sig je); Small inducible cytokine A2; Small inducible cytokine subfamily A (Cys Cys), member 2; Small inducible cytokine subfamily A Cys Cys member 2; Small-inducible cytokine A2; SMC CF; SMC-CF; SMCCF.
literatures	Specific References  (19)     |     SL1101R has been referenced in 19 publications. [IF=6.17] Tong Xu. et al. Lithium chloride represses abdominal aortic aneurysm via regulating GSK3β/SIRT1/NF-κB signaling pathway. Free Radical Bio Med. 2021 Apr;166:1  IHC ;  Rat.   PubMed:33588051 [IF=5.01] Jeong, Keun‐Yeong, et al. "Irradiation‐induced localization of IL‐12‐expressing mesenchymal stem cells to enhance the curative effect in murine metastatic hepatoma." International Journal of Cancer (2015).  WB ;  Mouse.   PubMed:25639194 [IF=4.996] Yagi Misaki. et al. Comparison of the effects of oxidative and inflammatory stresses on rat chondrocyte senescence. SCI REP-UK. 2023 May;13(1):1-13  WB ;  Rat.   PubMed:37169906 [IF=4.75] Guo et al. Effect of telmisartan on the expression of adiponectin receptors and nicotinamide adenine dinucleotide phosphate oxidase in the heart and aorta in type 2 diabetic rats. (2012) Cardiovasc.Diabetol. 11:94  IHC ;  Rat.   PubMed:22873349 [IF=4.6] Iwasa, Akihiko, et al. "Aromatase Controls Sjögrens Syndrome–Like Lesions through Monocyte Chemotactic Protein-1 in Target Organ and Adipose Tissue–Associated Macrophages." The American Journal of Pathology (2014).  IHC-P ;  Mouse.   PubMed:25447050 [IF=4.307] Mayuko Ichimura-Shimizu. et al. A novel mouse model of non-alcoholic steatohepatitis suggests that liver fibrosis initiates around lipid-laden macrophages. Am J Pathol. 2021 Oct;:  IF ;  Mouse.   PubMed:34710382 [IF=4.225] Jianwei Fan. et al. Baicalin Ameliorates Pancreatic Fibrosis by Inhibiting the Activation of Pancreatic Stellate Cells in Mice with Chronic Pancreatitis. Front Pharmacol. 2020; 11: 607133  IHC ;  Mouse.   PubMed:33536916 [IF=3.571] Zheng HX et al. Cyanidin-3-glucoside from Black Rice Ameliorates Diabetic Nephropathy via Reducing Blood Glucose, Suppressing Oxidative Stress and Inflammation, and Regulating Transforming Growth Factor β1/Smad Expression. J Agric Food Chem. 2020 Apr 15;68(15):4399-4410.  IHC-P ;  Rat.   PubMed:32192334 [IF=3.361] Gao X et al. Inhibition of LOX-1 prevents inflammation and photoreceptor cell death in retinal degeneration. Int Immunopharmacol. 2020 Mar;80:106190.  WB ;  Mouse.   PubMed:31945611 [IF=3.25] Kugo, Hirona, et al. "Suppressive effects of dietary EPA-rich fish oil on the degradation of elastin fibers in the aortic wall in nicotine-administered mice." Food & Function (2017).  IHC-F ;  Mouse.   PubMed:28725903 [IF=2.88] He et al. Combined Microencapsulated Islet Transplantation and Revascularization of Aortorenal Bypass in a Diabetic Nephropathy Rat Model. (2016) J.Diabetes.Res. 2016:9706321  IHC ;  Rat.   PubMed:27119088 [IF=2.784] Zhang et al. Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/β-catenin signaling pathway. (2018) Int.J.Mol.Med. 42:3344-3354  WB ;  Human.   PubMed:30272329 [IF=2.5] Kuracha, Murali R., et al. "Patient‐derived xenograft mouse models of pseudomyxoma peritonei recapitulate the human inflammatory tumor microenvironment." Cancer Medicine (2016).  IHC-P ;  Mouse.   PubMed:26833741 [IF=2.464] Zhou, Taocheng. et al. Leonurine Alleviates Alcoholic Steatohepatitis Through the TLR4/NF-κB Signalling Pathway. Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy. 2022 Aug;:1-15  WB ;  Mouse.   PubMed:10.1007/s43450-022-00284-4 [IF=2.21] Su, Xuesong, et al. "The PPARβ/δ Agonist GW501516 Attenuates Peritonitis in Peritoneal Fibrosis via Inhibition of TAK1–NFκB Pathway in Rats."Inflammation 37.3 (2014): 729-737.  WB ;  Rat.   PubMed:24337677 [IF=1.69] Li et al. Curcumin attenuates the development of thoracic aortic aneurysm by inhibiting VEGF expression and inflammation. (2017) Mol.Med.Rep. 16:4455-4462  WB ;  Human, Rat.   PubMed:28791384 [IF=1.64] Guo, Wei, et al. "Transplantation of endothelial progenitor cells in treating rats with IgA nephropathy." BMC Nephrology 15.1 (2014): 110.  IHC-P ;  Rat.   PubMed:25012471 [IF=1.182] Miyamoto C et al. Effect of a High-sucrose Diet on Abdominal Aortic Aneurysm Development in a Hypoperfusion-induced Animal Model.J Oleo Sci. 2018 May 1;67(5):589-597.  IHC ;  Rat.   PubMed:29628493 [IF=0] Hamidy MY et al. Effect of Andrographolide on Monocyte Chemoattractant Protein-1 Expression at the Initiation Stage of Atherosclerosis in Atherogenic Diet-Fed Rats. Biomed Pharmacol J 2019;12(3).  IHC-P ;  Rat.   PubMed:DOI:10.13005/bpj/1745
Research Area	Tumour  immunology  transcriptional regulatory factor
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse, Rat,
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	11kDa
Cellular localization	Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from rat MCP-1: 61-148/148
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. Processing at the N-terminus can regulate receptor and targetcell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant. Genetic variations in CCL2 determine Mycobacterium tuberculosis susceptibility Belongs to the intercrine beta (chemokine CC) family. The MCP-1( the monocyte chemotactic protein1) has many pits that regulates the function toward sex to turn to record the factor, it can induce to have relation with inflammation with the immunity various genes turn to record.The immunity MCP-1 set turns the male signal to mainly locate the afterbirth syrup inside. Function: Chemotactic factor that attracts monocytes and basophils but not neutrophils or eosinophils. Augments monocyte anti-tumor activity. Has been implicated in the pathogenesis of diseases characterized by monocytic infiltrates, like psoriasis, rheumatoid arthritis or atherosclerosis. May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis. Subunit: Monomer or homodimer; in equilibrium. Binds to CCR2 and CCR4. Is tethered on endothelial cells by glycosaminoglycan (GAG) side chains of proteoglycans. Subcellular Location: Secreted. Post-translational modifications: Processing at the N-terminus can regulate receptor and target cell selectivity. Deletion of the N-terminal residue converts it from an activator of basophil to an eosinophil chemoattractant. Similarity: Belongs to the intercrine beta (chemokine CC) family. SWISS: P14844 Gene ID: 24770 Database links: Entrez Gene: 6347 Human Entrez Gene: 20296 Mouse Entrez Gene: 24770 Rat Omim: 158105 Human SwissProt: P13500 Human SwissProt: P10148 Mouse SwissProt: P14844 Rat Unigene: 303649 Human Unigene: 290320 Mouse Unigene: 4772 Rat Growth factors and hormones（ Growth Factor and Hormones） 巨噬细胞趋化蛋白1(MCP1)具有多向性调节作用的核转录因子，它可诱导与免疫和炎症有关的多种基因转录.MCP-1免疫组化阳性信号主要位于胞浆内。 单核细胞趋化蛋白-1（monocyte chemotactic protein 1,MCP-1)又称单核细胞趋化和激活因子（monoctye chemotactic and activating factor,MCAF)，属于C-C亚族（β亚族）成员。MCP-1/MCAF起初是从人髓样单核细胞系THP-1、神经胶质瘤细胞系以及LPS或PHA刺激的人PBMC培养上清中发现。目前已知，单核细胞、巨噬细胞、成纤维细胞、endothelial cells、B细胞、平滑肌细胞等在PHA、LPS、Poly I-C、IL-1、IFN-γ、PDGF、EGF或某些病毒刺激下均可被诱导分泌MCP-1。某些Tumour细胞系则可组成性产MCP-1。
Product Picture	Paraformaldehyde-fixed, paraffin embedded (rat lung); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (MCP1) Polyclonal Antibody, Unconjugated (SL1101R ) at 1:200 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Tissue/cell: mouse kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-MCP-1 Polyclonal Antibody, Unconjugated(SL1101R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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