Product Name	SOCS6
Chinese Name	cell factor信号传导抑制蛋白6抗体
Alias	CIS-4; CIS4; Cish4; Cytokine inducible SH2 protein 4; Cytokine-inducible SH2 protein 4; HSPC060; SOCS-4; SOCS-6; SOCS4; Socs6; SOCS6_HUMAN; SSI4; STAI4; STAT induced STAT inhibitor 4; STAT4; STATI4; Suppressor of cytokine signaling 4; Suppressor of cytokine signaling 6.
Research Area	Cell biology  Signal transduction
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	59kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human SOCS6: 21-120/535
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]. Function: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor. Subunit: Interacts with RBCK1. Interacts with phosphorylated IRS4. Interacts with PIM3. Interacts with KIT (phosphorylated). Similarity: Contains 1 SH2 domain. Contains 1 SOCS box domain. SWISS: O14544 Gene ID: 9306 Database links: Entrez Gene: 9306 Human Entrez Gene: 54607 Mouse Omim: 605118 Human SwissProt: O14544 Human SwissProt: Q9JLY0 Mouse Unigene: 44439 Human Unigene: 476577 Mouse Unigene: 91920 Mouse
Product Picture	Sample: Heart (Chicken) Lysate at 40 ug Primary: Anti- SOCS6 (SL10685R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 59 kD Observed band size: 60 kD Sample: Heart (Mouse) Lysate at 40 ug Primary: Anti- SOCS6 (SL10685R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 59 kD Observed band size: 57 kD

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