Product Name	FBXO42
Chinese Name	FBXO42蛋白抗体
Alias	F box only protein 42; F box protein 42; FBX42; FBXO 42; KIAA1332; FBX42_HUMAN.
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Mouse,  (predicted: Human, Rat, Chicken, Dog, Cow, Horse, Rabbit, Sheep, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	78kDa
Cellular localization	The nucleus
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human FBXO42: 621-717/717
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	FBXO42 (F-box only protein 42) is a 717 amino acid protein that contains four Kelch repeats and one N-terminal F-box domain, and belongs to the F-box family of proteins. F-box proteins are critical components of the SCF (Skp1-CUL-1-F-box protein) type E3 ubiquitin ligase complex and are involved in substrate recognition and recruitment for ubiquitination. They are members of a larger family of proteins that are involved in the regulation of a wide variety of cellular processes (including the cell cycle, immune response, signaling cascades and developmental processes) through the targeting of proteins, such as cyclins, cyclin-dependent kinase inhibitors, IkB-a and b-catenin, for degradation by the proteasome after ubiquitination. Function: Substrate-recognition component of some SCF(SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.Specifically recognizes p53/TP53, promoting its ubiquitination anddegradation. Subunit: Component of some SCF complex, composed of CUL1, SKP1,RBX1 and FBXO42. Interacts (via the kelch domain) with p53/TP53;interaction is direct. Tissue Specificity: Expressed at moderate levels in liver, ovary, kidney, testis and adult brain, and at low levels in heart and fetal brain, FBXO42 directly interacts with Skp1 p19 and CUL-1. Similarity: Contains 1 F-box domain. Contains 4 Kelch repeats. SWISS: Q6P3S6 Gene ID: 54455 Database links: Entrez Gene: 54455 Human Omim: 609109 Human SwissProt: Q6P3S6 Human Unigene: 522384 Human
Product Picture	Tissue/cell: mouse kidney tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-FBXO42 Polyclonal Antibody, Unconjugated(SL10560R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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