Product Name	DRD2
Chinese Name	多巴胺受体D2抗体
Alias	DRD2_HUMAN; D(2) dopamine receptor; Dopamine D2 receptor; dopamine receptor D2; D2R; D2DR;
literatures	Specific References  (11)     |     SL1008R has been referenced in 11 publications. [IF=11.685] Kristine Elisabeth Eberhard. et al. Neurotransmitter and Neurotransmitter Receptor Expression in the Saccule of the Human Vestibular System. Prog Neurobiol. 2022 Jan;:102238  IHC ;  Human.   PubMed:35104536 [IF=8.46] Zhang, Q. B., et al. "Moderate swimming suppressed the growth and metastasis of the transplanted liver cancer in mice model: with reference to nervous system." Oncogene (2016).  WB ;  Human.   PubMed:26686088 [IF=4.181] Bai L et al. m6A demethylase FTO regulates dopaminergic neurotransmission deficits caused by arsenite.Toxicol Sci. 2018 Oct 1;165(2):431-446.  WB ;  Mouse.   PubMed:29982692 [IF=3.26] Salgado, R., et al. "Perfluorooctane sulfonate (PFOS) exposure could modify the dopaminergic system in several limbic brain regions." Toxicology Letters(2015).  WB ;  Rat.   PubMed:26529483 [IF=2.88] Yano, Shigetoshi, et al. "Mixed pituitary gangliocytom and prolactinoma resistant to the cabergoline treatment: A case report." World Neurosurgery(2016).  IHC-P ;  Human.   PubMed:27535625 [IF=2.629] Bian Li-hua. et al. Nardosinone Alleviates Parkinson’s Disease Symptoms in Mice by Regulating Dopamine D2 Receptor. Evid-Based Compl Alt. 2021;2021:6686965  WB ;  Mouse.   PubMed:34426745 [IF=2.35] Xu, Jiao-jiao, et al. "Dopamine D1 receptor activation induces dehydroepiandrosterone sulfotransferase (SULT2A1) in HepG2 cells." Acta Pharmacologica Sinica (2014).  WB ;  Human.   PubMed:24909515 [IF=1.966] Tian L et al. Gingerol inhibits cisplatin-induced acute and delayed emesis in rats and minks by regulating the central and peripheral 5-HT, SP, and DA systems. J Nat Med. 2019 Nov 25.  IHC-P ;  rat&mink.   PubMed:31768887 [IF=1.44] Hu et al. Increased extracellular dopamine and 5-hydroxytryptamine levels contribute to enhanced subthalamic nucleus neural activity during exhausting exercise. (2015) Biol.Sport. 32:187-92  IHC ;  Rat.   PubMed:26424920 [IF=0.93] Mao, Min, et al. "Dopamine D2 receptor blocker thioridazine induces cell death in human uterine cervical carcinoma cell line SiHa." Journal of Obstetrics and Gynaecology Research (2015).  IHC-P ;  Human.   PubMed:25832589 [IF=0.64] Qian, Weibin, et al. "Effect of Gingerol on Cisplatin-Induced Pica Analogous to Emesis Via Modulating Expressions of Dopamine 2 Receptor, Dopamine Transporter and Tyrosine Hydroxylase in the Vomiting Model of Rats."Yonago Acta medica 59 (2016): 100-110.  IHC-F ;  Rat.   PubMed:27493480
Research Area	Tumour  Cell biology  immunology  Neurobiology  Signal transduction  The cell membrane受体  G protein-coupled receptor  G protein signal
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Rat,  (predicted: Human, Mouse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:200-800 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	51kDa
Cellular localization	cytoplasmic The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human DRD2: 201-300/443 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene encodes the D2 subtype of the dopamine receptor. This G-protein coupled receptor inhibits adenylyl cyclase activity. A missense mutation in this gene causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing of this gene results in two transcript variants encoding different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. [provided by RefSeq, Jul 2008] Function: This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Subcellular Location: Cell membrane. DISEASE: Defects in DRD2 are associated with dystonia type 11 (DYT11) [MIM:159900]; also known as alcohol-responsive dystonia. DYT11 is a myoclonic dystonia. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. DYT11 is characterized by involuntary lightning jerks and dystonic movements and postures alleviated by alcohol. Inheritance is autosomal dominant. The age of onset, pattern of body involvement, presence of myoclonus and response to alcohol are all variable. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: P14416 Gene ID: 1813 Database links: Entrez Gene: 1813 Human Entrez Gene: 13489 Mouse Entrez Gene: 24318 Rat SwissProt: P14416 Human SwissProt: P61168 Mouse SwissProt: P61169 Rat DAD2主要用于多态性与精神分裂症方面的研究.
Product Picture	Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Dopamine D2 Receptor) Polyclonal Antibody, Unconjugated (SL1008R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. Paraformaldehyde-fixed, paraffin embedded (Rat brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (Dopamine D2 Receptor) Polyclonal Antibody, Unconjugated (SL1008R) at 1:400 overnight at 4°C, followed by a conjugated Goat Anti-Rabbit IgG antibody (SL0295G-AF488) for 90 minutes, and DAPI for nuclei staining.

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