Product Name	VCAM1
Chinese Name	vascular endothelial cell粘附分子（CD106）抗体
Alias	CD 106; CD106; CD106 Antigen; DKFZp779G2333; INCAM 100; MGC99561; Vascular Cell Adhesion Molecule 1; Vascular cell adhesion protein 1; VCAM 1; VCAM-1; INCAM-100; V-CAM 1; VCAM1_HUMAN.
literatures	Specific References  (17)     |     SL0920R has been referenced in 17 publications. [IF=16.834] Bartko, Philipp E., et al. "Effect of Losartan on Mitral Valve Changes After Myocardial Infarction." Journal of the American College of Cardiology 70.10 (2017): 1232-1244.  ICC ;  Sheep.   PubMed:28859786 [IF=16.806] Jianting Yao. et al. Low-Intensity Focused Ultrasound-Responsive Ferrite-Encapsulated Nanoparticles for Atherosclerotic Plaque Neovascularization Theranostics. 2021 Aug 11  IF ;  Rabbit.   PubMed:34382370 [IF=7.901] Shim W et al. Catechin solubilization by spontaneous hydrogen bonding with poly(ethylene glycol) for dry eyetherapeutics. J Control Release. 2019 May 20.  IHC-P ;  Mouse.   PubMed:31121276 [IF=7.901] Shim W et al. Catechin solubilization by spontaneous hydrogen bonding with poly(ethylene glycol) for dry eyetherapeutics. J Control Release. 2019 May 20.  IHC-P ;  Mouse.   PubMed:31121276 [IF=7.126] Vendrov AE et al.NOXA1-dependent NADPH oxidase regulates redox signaling and phenotype of vascular smooth muscle cell during atherogenesis.Redox Biol. (2018) Redox Biol. 21:101063.  IHF ;  Mouse.   PubMed:30576919 [IF=5.23] Kim, Chae Eun, et al. "Effects of silk fibroin in murine dry eye." Scientific Reports 7 (2017): 44364.  IHC-F ;  Mouse.   PubMed:28281688 [IF=5.21] Ma, Yanqin, et al. "Inflammatory responses induced by fluoride and arsenic at toxic concentration in rabbit aorta." Archives of toxicology 86.6 (2012): 849-856.  WB ;  Rabbit.   PubMed:22422340 [IF=5.11] Vendrov, Aleksandr E., et al. "Attenuated Superoxide Dismutase 2 Activity Induces Atherosclerotic Plaque Instability During Aging in Hyperlipidemic Mice." Journal of the American Heart Association 6.11 (2017): e006775.  IHC-F ;  Mouse.   PubMed:29079564 [IF=4.87] Lozhkin, Andrey, et al. "NADPH oxidase 4 regulates vascular inflammation in aging and atherosclerosis." Journal of Molecular and Cellular Cardiology (2016).  IHC-F ;  Mouse.   PubMed:27986445 [IF=4.522] Zhao H et al. miR‐181a/b‐5p ameliorates inflammatory response in monocrotaline‐induced pulmonary arterial hypertension by targeting endocan. J Cell Physiol. 2019 Oct 21.  WB ;  Rat.   PubMed:31637717 [IF=4.456] Bohui Xiong. et al. LncRNA8276 primes cell–cell adhesion for regulation of spermatogenesis. ANDROLOGY-US. 2022 Sep;:  IF ;  Mouse.   PubMed:36116016 [IF=3.213] Tang et al. The renoprotective effects of berberine and its potential impact on the expression of β-arrestins and ICAM-1/VCAM-1 in streptozocin induced-diabetic nephropathy rats. (2015) J.Diabetes.  IHC-P/WB ;  rat.   PubMed:26531813 [IF=2.784] Zhang et al. Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/β-catenin signaling pathway. (2018) Int.J.Mol.Med. 42:3344-3354  WB ;  Human.   PubMed:30272329 [IF=2.766] Belcher et al. Haptoglobin and hemopexin inhibit vaso-occlusion and inflammation in murine sickle cell disease: Role of heme oxygenase-1 induction. (2018) PLoS.One. 13:e0196455  IF ;  mouse.   PubMed:29694434 [IF=2.086] Park EY et al. Sulglycotide ameliorates inflammation in lipopolysaccharide-stimulated mouse macrophage cells by blocking the NF-κB signaling pathway. Immunopharmacol Immunotoxicol. 2019 Jun 23:1-8.  WB&ICF ;  Mouse.   PubMed:31232125 [IF=1.93] Tang, Li‐Qin, et al. "The renoprotective effects of berberine and its potential impact on the expression of β‐arrestins and ICAM‐1/VCAM‐1 in streptozocin induced‐diabetic nephropathy rats." Journal of Diabetes (2015).  other ;   PubMed:26531813 [IF=1.28] Mu, Wei, et al. "Expression of vascular cell adhesion molecule-1 in the aortic tissues of atherosclerotic patients and the associated clinical implications." Experimental and therapeutic medicine 10.2 (2015): 423-428.  IHC-P ;  Human.   PubMed:26622332
Research Area	Tumour  Cardiovascular  Cell biology  Cell adhesion molecule  endothelial cells
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rabbit, Sheep,  (predicted: Rat, Pig, )
Applications	WB=1:500-2000 ELISA=1:5000-10000  not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	81kDa
Detection molecular weight	110 kDa
Cellular localization	The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human VCAM-1: 651-739/739 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2010] Function: Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. Subunit: Binds to ECMV-D capsid proteins and acts as a receptor for this virus. Subcellular Location: Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Lipid-anchor, GPI-anchor. Tissue Specificity: Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Expressed in the bone marrow. Similarity: Contains 7 Ig-like C2-type (immunoglobulin-like) domains. SWISS: P19320 Gene ID: 7412 Database links: Entrez Gene: 7412 Human Entrez Gene: 22329 Mouse Entrez Gene: 25361 Rat SwissProt: P19320 Human SwissProt: P29533 Mouse
Product Picture	Sample: VCAM1 protein (Human) at 100 ng Primary: Anti-VCAM1 (SL0920R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 81 kD Observed band size: 78 kD

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