Product Name	CTGF
Chinese Name	结缔组织生长因子抗体
Alias	CCN 2; CCN-2; CCN2; Connective Tissue Growth Factor; Hcs 24; Hcs24; Hypertrophic chondrocyte specific protein 24; Hypertrophic chondrocyte-specific gene product 24; Insulin-like Growth Factor-Binding Protein 8; MGC102839; NOV 2; NOV2; Connective tissue growth factor; CCN family member 2; Hypertrophic chondrocyte-specific protein 24; Insulin-like growth-binding protein 8; IBP-8; IGF-binding protein 8; IGFBP8; IGFBP-8; connective tissue growth factor precursor; CTGF_HUMAN.
literatures	Specific References  (13)     |     SL0743R has been referenced in 13 publications. [IF=8.46] Ciamporcero, E., et al. "YAP activation protects urothelial cell carcinoma from treatment-induced DNA damage." Oncogene (2015).  WB ;  Human.   PubMed:26119935 [IF=6.854] Ciamporcero et al. YAP activation protects urothelial cell carcinoma from treatment-induced DNA damage. (2016) Oncogene. 35:1541-53  WB ;  Human.   PubMed:26119935 [IF=4.486] Deng Z et al. Dabigatran ameliorates airway smooth muscle remodeling in asthma by modulating Yes‐associated protein. J Cell Mol Med. 2020 Jul;24(14):8179-8193.  WB&ICF ;  Mouse&Human.   PubMed:32542982 [IF=4.486] Deng Z et al. Dabigatran Ameliorates Airway Smooth Muscle Remodeling in Asthma by Modulating Yes-associated Protein. J Cell Mol Med. 2020 Jun 15.  WB ;  mouse.   PubMed:32542982 [IF=4.174] Zhao, Boyuan. et al. Shear stress regulates the migration of suspended breast cancer cells by nuclear lamina protein A/C and large tumor suppressor through yes-associated protein. Hum Cell. 2022 Jan;:1-16  WB ;  Human.   PubMed:34984662 [IF=4.101] Yu Guo. et al. RepSox effectively promotes the induced differentiation of sheep fibroblasts into adipocytes via the inhibition of the TGF‑β1/Smad pathway. Int J Mol Med. 2021 Aug;48(2):1-13  WB ;  Sheep.   PubMed:34132357 [IF=3.423] Zhe Sui. et al. Ginsenoside Rg3 has effects comparable to those of ginsenoside re on diabetic kidney disease prevention in db/db mice by regulating inflammation, fibrosis and PPARγ. MOL MED REP. 2023 Apr;27(4):1-10  IHC ;  Mouse.   PubMed:36866725 [IF=2.24] Tian, Yanyan, et al. "Effects of vitamin D on renal fibrosis in diabetic nephropathy model rats." International Journal of Clinical and Experimental Pathology 7.6 (2014): 3028-3037.  IHC-P ;  Rat.   PubMed:25031721 [IF=1.922] Chi et al. Transdermal estrogen gel and oral aspirin combination therapy improves fertility prognosis via the promotion of endometrial receptivity in moderate to severe intrauterine adhesion. (2018) Mol.Med.Rep. 17:6337-6344  IHC ;  Human.   PubMed:29512784 [IF=1.922] Zhang et al. Apelin-13 protects against myocardial infarction-induced myocardial fibrosis. (2016) Mol.Med.Rep. 13:5262-8  IHC-P/WB ;  Rat.   PubMed:27109054 [IF=1.74] Al-hamilly, Nadia Saeed, et al. "Biological roles of KGF, CTGF and TGF-β in cyclosporine-A-and phenytoin-induced gingival overgrowth: A comparative experimental animal study." Archives of oral biology 66 (2016): 38-43.  IHC-P ;  Rat.   PubMed:26894526 [IF=1.405] Han et al. MicroRNA-145 Inhibits Cell Migration and Invasion and Regulates Epithelial-Mesenchymal Transition (EMT) by Targeting Connective Tissue Growth Factor (CTGF) in Esophageal Squamous Cell Carcinoma. (2016) Med.Sci.Moni. 22:3925-3934  IHC-P ;  Human.   PubMed:27771733 [IF=1.069] He, Hongying, et al. "Carbamylated erythropoietin ameliorates cardiomyopathy via ERK (44/42) activation in rats with diabetic cardiomyopathy." Int J Clin Exp Med 10.10 (2017): 14213-14222.  IHC-P ;  Rat.   PubMed:ISSN:1940-5901/IJCEM0055711
Research Area	Cardiovascular  immunology  Growth factors and hormones
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	36kDa
Cellular localization	Extracellular matrix Secretory protein
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human CTGF: 221-349/349
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The protein encoded by this gene is a mitogen that is secreted by vascular endothelial cells. The encoded protein plays a role in chondrocyte proliferation and differentiation, cell adhesion in many cell types, and is related to platelet-derived growth factor. Certain polymorphisms in this gene have been linked with a higher incidence of systemic sclerosis. [provided by RefSeq, Nov 2009]. Function: Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis. Subunit: Monomer. Subcellular Location: Secreted, extracellular space, extracellular matrix. Secreted. Tissue Specificity: Expressed in bone marrow and thymic cells. Also expressed one of two Wilms tumors tested. Similarity: Belongs to the CCN family. Contains 1 CTCK (C-terminal cystine knot-like) domain. Contains 1 IGFBP N-terminal domain. Contains 1 TSP type-1 domain. Contains 1 VWFC domain. SWISS: P29279 Gene ID: 1490 Database links: Entrez Gene: 1490 Human Entrez Gene: 64032 Rat Omim: 121009 Human SwissProt: P29279 Human SwissProt: P29268 Mouse SwissProt: Q9R1E9 Rat Unigene: 410037 Human Unigene: 390287 Mouse Growth factors and hormones（ Growth Factor and Hormones） 结缔组织生长因子（CTGF）是调节细胞增生、分化和Extracellular matrix形成的重要效应分子,可调节机体有关组织、细胞生长并与纤维化发生密切相关的一种因子，因而在肌体的各类创伤修复过程中具有重要的生理学意义。
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