Product Name	ABCG2
Chinese Name	三磷酸腺苷结合TransporterG超家族成员2抗体
Alias	ABC15; ABCG 2; ABCG2_HUMAN; ABCP; ATP binding cassette sub family G (WHITE) member 2; ATP binding cassette transporter G2; ATP-binding cassette sub-family G member 2; BCRP1; BMDP; Breast cancer resistance protein; CD338; CDw338; CDw338 antigen; EST157481; GOUT1; MGC102821; Mitoxantrone resistance associated protein; Mitoxantrone resistance-associated protein; MRX; Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2; MXR; MXR1; Placenta specific ATP binding cassette transporter; Placenta specific MDR protein; Placenta-specific ATP-binding cassette transporter; UAQTL1.
literatures	Specific References  (10)     |     SL0662R has been referenced in 10 publications. [IF=4.073] Le Y et al. Anti-Hyperuricemic Effects of Astaxanthin by Regulating Xanthine Oxidase, Adenosine Deaminase and Urate Transporters in RatsMar Drugs.2020 Dec 1;18(12):610.  WB ;  Rat.   PubMed:33271765 [IF=3.776] Dongming Chen. et al. Study on the mechanism of Phellinus igniarius total flavonoids in reducing uric acid and protecting uric acid renal injury in vitro. HELIYON. 2023 Jan;9:e12979  WB ;  Human.   PubMed:10.1016/j.heliyon.2023.e12979 [IF=3.73] Huanhuan Wang. et al. The Pigments in Eggshell with Different Color and the Pigment Regulatory Genes Expression in Corresponding Chicken’s Shell Gland. ANIMAL. 2023 Mar;:100776  WB,IHC ;  Chicken.   PubMed:37043933 [IF=3.61] Skoda, Jan, et al. "Cancer stem cell markers in pediatric sarcomas: Sox2 is associated with tumorigenicity in immunodeficient mice." Tumor Biology(2016): 1-14.  IHC-P ;  Human.   PubMed:26790443 [IF=3.577] Yuan-Jian Hui. et al. Up-regulation of ABCG2 by MYBL2 deletion drives Chlorin e6-mediated photodynamic therapy resistance in colorectal cancer. PHOTODIAGN PHOTODYN. 2023 Apr;:103558  WB ;  Human.   PubMed:37030434 [IF=2.969]  Xue Zhou . et al. Let-7b regulates the adriamycin resistance of chronic myelogenous leukemia by targeting AURKB in K562/ADM cells. Leukemia Lymphoma. 2020;61(14):3451-3459  WB ;  Human.   PubMed:32856506 [IF=2.825] Yan Shou Zhang. et al. Expression of BCRP/ABCG2 Protein in Invasive Breast Cancer and Response to Neoadjuvant Chemotherapy. Oncol Res Treat. ;:  IHC ;  Human.   PubMed:34775385 [IF=1.902] Wang J et al. Effects of duration of thermal stress on growth performance, serum oxidative stress indices, the expression and localization of ABCG2 and mitochondria ROS production of skeletal muscle, small intestine and immune organs in broilers. J Therm Biol. 2019 Oct;85:102420.  IHC-P ;  broiler.   PubMed:31657761 [IF=1.35] Su, L., et al. "Effect of colibacillosis or coccidiosis on expression of breast cancer resistance protein in small intestine and liver of chickens." Journal of Veterinary Pharmacology and Therapeutics (2013).  WB ;  Chicken.   PubMed:23531049 [IF=1.291] Duan CY et al. Limbal niche cells can reduce the angiogenic potential of cultivated oral mucosal epithelial cells. Cell Mol Biol Lett. 2019 Apr 4;24:3.  ICF ;  Rat.   PubMed:30988673
Research Area	immunology  Neurobiology  Stem cells  Transporter  Cell Surface Molecule
Immunogen Species	Rabbit
Clonality	Polyclonal
React Species	Human, Rat,  (predicted: Mouse, )
Applications	WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （Paraffin sections need antigen repair） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
Theoretical molecular weight	72kDa
Cellular localization	The nucleus The cell membrane
Form	Liquid
Concentration	1mg/ml
immunogen	KLH conjugated synthetic peptide derived from human ABCG2: 571-655/655 <Cytoplasmic>
Lsotype	IgG
Purification	affinity purified by Protein A
Buffer Solution	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Storage	Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
Attention	This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMed	PubMed
Product Detail	The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012] Function: Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123. Subunit: Monomer or homodimer; disulfide-linked. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Highly expressed in placenta. Low expression in small intestine, liver and colon. Similarity: Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily. Contains 1 ABC transmembrane type-2 domain. Contains 1 ABC transporter domain. SWISS: Q9UNQ0 Gene ID: 9429 Database links: Entrez Gene: 9429 Human Omim: 603756 Human SwissProt: Q9UNQ0 Human Unigene: 480218 Human Hematopoietic/Neural Stem Cell Marker （造血/神经Stem cellsMaker)
Product Picture	Sample: Lane 1: Mouse Placenta tissue lysates Lane 2: Mouse Cerebrum tissue lysates Lane 3: Mouse Lung tissue lysates Lane 4: Rat Placenta tissue lysates Lane 5: Rat Cerebrum tissue lysates Lane 6: Rat Lung tissue lysates Lane 7: Human MCF-7 cell lysates Lane 8: Human HepG2 cell lysates Lane 9: Human HUVEC cell lysates Primary: Anti-ABCG2 (SL0662R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 72 kDa Observed band size: 82 kDa Tissue/cell: human placenta tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-ABCG2/CD338 Polyclonal Antibody, Unconjugated(SL0662R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: rat brain tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-ABCG2/CD338 Polyclonal Antibody, Unconjugated(SL0662R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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